Inhibition of the carcinogenic action of benzo(a)pyrene by flavones.

نویسندگان

  • L W Wattenberg
  • J L Leong
چکیده

The inducers of increased B? hydroxylase activity which have been selected for use in the present work are 3 flavones with widely differing capacities to induce increased B? hydroxylase activity (1 5). The most active of the 3 is @3-naphthofiavone (5,6-benzofiavone), a synthetic compound. Of all flavones tested thus far, j3-naphthoflavone is the most potent inducer of increased B? hydroxylase activity. The 2nd flavone selected is quercetin pentamethyl ether (3,3',4',5,7pentamethoxyflavone), which is of intermediate potency as an inducer. This compound has an inducing capacity similar to tangeretin (5,6,7,8,4'-pentamethoxyfiavone) and nobiletin (5,6,7,8,3'4,4'-hexamethoxyfiavone), whichare the most potent of the naturally occurring flavone inducers of increased B? hydroxylase activity which have been studied. Like these 2 compounds, it is totally methylated. The 3rd fiavone chosen for study is rutin (3,3',4@,5,7-pentahydroxyfiavone 3-rutinoside), a naturally occurring compound which is a very weak inducer. Two experimental carcinogenesis systems have been studied. The first of these is pulmonary adenoma formation in mice receiving B? by p.o. intubation subsequent to administration of inducers. In this experimental system, the carcinogen traverses tissues with B? hydroxylase activity prior to reaching the target organ in which neoplasms develop. The second experimental system studied is epidermal tumor formation in the mouse. In the procedure used, topical application of B? was used to initiate tumor formation (1) subsequent to administration of inducer. In this instance, there is direct contact of carcinogen with the target tissue.

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عنوان ژورنال:
  • Cancer research

دوره 30 7  شماره 

صفحات  -

تاریخ انتشار 1970